Science News

Antidepressants Overprescribed: Dubious Approval Haunts Suicides


On Friday, Sept. 8, 2023, a gorgeous late summer day in Wisconsin, Dale Niggemann came home and saw a note left on the door by Maggie Stern, 55, his best friend and partner for the past five years.

The note said, “Call 911.” First responders arrived at their home and discovered Ms. Stern’s body.

“She said she was in a lot of pain all the time,” said Mr. Niggemann, 57, who was at Ms. Stern’s side as she struggled with the adverse effects of an antidepressant—and painful withdrawal symptoms each time she tried to wean off them.

“She suffered from migraine headaches, tremors, burning pain sensations in her nerves, and dark thoughts about demons and hell.“ Mr. Niggemann said Maggie knew she had everything to live for, but the pain, caused by the effects of the medication, was too intense. ”Her teeth were grinding down, her toes were curled. That is what these antidepressants do.”

image-5581469

Dale Niggemann and Maggie Stern. (Courtesy of Dale Niggemann)

The most common antidepressants prescribed for depression are selective serotonin reuptake inhibitors (SSRIs). However, a study published in 2022 highlights the controversy over whether the use of SSRIs to increase available serotonin in the brain can alleviate depression.

More Articles

Off-label and additional uses of antidepressants are important market segments for drug makers. The total market for antidepressants was $15.6 billion in 2022 and projected to reach $23.22 billion by 2030, according to market research firm SNS Insider.
Estimates of overprescription range widely from 20 percent among the general population to 24 percent or more among the elderly.
In an article for the American Psychological Association, Steven Hollon, a psychology professor at Vanderbilt University who researches the effectiveness of antidepressants, suggested the rate could be much higher.

Seeking Relief Leads to Suffering

About 20 years ago, Ms. Stern was prescribed the SSRI Zoloft (generic name sertraline) after complaining to a doctor of anxiety as she prepared to move from Wisconsin to Alaska to start a new chapter of her life.

Mr. Niggemann said her doctor told her it was a “brain vitamin.” Ms. Stern told him that the doctor did not inform her of possible adverse effects.

Two weeks after Ms. Stern’s death, Mr. Niggemann found her suicide note—the last entry in her pain journal:

“If you read this journal, you will have an idea how hard I worked/tried to survive.
”The Pharma crap killed my body, but not my spirit.
“I’m still me. But the PAIN is too much to endure.
“Please educate/ADVOCATE against All Pharma Drugs, especially vaccines & ‘antidepressants.’”

Although the suicides of people who use antidepressant drugs are often blamed on their depression, a rising chorus of family members and physicians say the drugs themselves can lead to suicide as well as violent behavior, agitation, and depression.

Physician Alleges Drug Studies Misreported Suicide Risks

Dr. Peter C. Gøtzsche, an internal medicine physician based in Denmark and author of the book, “Deadly Psychiatry and Organised Denial,” is a leading critic of antidepressant drugs. He published an open letter (pdf) in August 2023 to two prominent medical journals, calling for “retraction of three fraudulent trial reports of antidepressants in children and adolescents.”

In the letter, he alleges that “the trial reports seriously underreported suicide attempts, other suicidal events, and precursors to suicide and violence on active drug, and exaggerated the benefits of the drugs substantially.”

Dr. Gøtzsche and Dr. David Healy, a psychiatrist and author of “The Antidepressant Era,” analyzed two placebo-controlled studies of fluoxetine, commonly known as Prozac, which led to their approved use for children and adolescents. Their examination of the original documents, published in 2022 in the International Journal of Risk & Safety in Medicine, concluded that “fluoxetine is unsafe and ineffective.”

Drs. Gøtzsche and Healy said the studies, which included 96 and 219 participants respectively, “appear to have been misreported.” Suicidal events that occurred during the trials were missing from the studies’ publications and reports. “Precursors to suicidality or violence occurred more often on fluoxetine than on placebo,” they said, and, “Patient ratings did not find fluoxetine effective.”

The 96-participant study (children 7 to 17 years old) concluded that “fluoxetine was superior to placebo in the acute phase treatment of … outpatients with severe, persistent depression.” This report was published in Archives of General Psychiatry, the precursor to JAMA Psychiatry.

The participants were divided into two groups of 48. One group took fluoxetine, the other group took a placebo.

The BMJ report found that the original paroxetine clinical study report said five patients exhibited suicidal or self-injurious behaviors, but the independent researchers found 11 patients in this category. The clinical study report by SmithKline Beecham, maker of paroxetine, had mostly misreported suicide-related events as “emotional lability.”
image-5581736

The U. S. Food and Drug Administration has asked makers of popular antidepressants to add or strengthen suicide-related warnings on their labels as well as the possibility of worsening depression, especially at the beginning of treatment or when the doses are increased or decreased. (Photo Illustration by Joe Raedle/Getty Images)

In light of the black box warnings associating antidepressants with suicide, several other researchers undertook studies to discover for themselves if there was a causal relationship. In a study published in 2006 in the Australian and New Zealand Journal of Psychiatry, researchers asked “How have the Selective Serotonin Reuptake Inhibitor Antidepressants Affected Suicide Mortality?”

Australian researchers, Dr. Wayne D. Hall, then professor of public health policy at University of Queensland, and Dr. Jayne Lucke, senior research fellow at the university, found that recent randomized controlled studies of SSRI antidepressants “increased suicidal ide



Source link

TruthUSA

I'm TruthUSA, the author behind TruthUSA News Hub located at https://truthusa.us/. With our One Story at a Time," my aim is to provide you with unbiased and comprehensive news coverage. I dive deep into the latest happenings in the US and global events, and bring you objective stories sourced from reputable sources. My goal is to keep you informed and enlightened, ensuring you have access to the truth. Stay tuned to TruthUSA News Hub to discover the reality behind the headlines and gain a well-rounded perspective on the world.

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.