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Metformin: Beyond Treating Diabetes


Research suggests that metformin may have multiple uses, including promoting longevity, aiding in weight loss, and offering protection against cancer.

Metformin, a common Type 2 diabetes medication, may provide protection against a subtype of age-related macular degeneration (AMD), as indicated by a study published in Investigative Ophthalmology & Vision Science (IOVS).

This latest study joins other research suggesting that metformin may have diverse benefits beyond diabetes, including promoting longevity, aiding in weight loss, and offering protection against neurological disorders, cancer, and cardiovascular disease. However, most of these potential uses are off-label, meaning that the U.S. Food and Drug Administration (FDA) has not approved the medication for these conditions.

While some studies show promising results for off-label metformin uses, others are inconsistent and controversial, as they may not provide the most effective approach for addressing certain health concerns. Additionally, although metformin is generally well-tolerated, it does have some adverse effects and may not be suitable for everyone.

Metformin and Macular Degeneration Subtype

Macular degeneration, a condition commonly associated with aging, affects the retina and leads to the loss of central vision. The primary types of AMD are wet AMD and dry AMD, with geographic atrophy (GA) being a subtype of dry AMD. GA can lead to legal blindness in 16 percent of those affected.



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