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New Review Shows How Persistent Weeds are Joining Forces to Battle Cancer


Potential anti-tumorigenic properties of various medicinal plants can be utilized in the battle against the majority of common types of cancer.

Recently, I conducted a presentation on edible plants at my local library. These were kitchen herbs that also serve as medicinal plants and can be easily grown in gardens or on windowsills. As I prepared for the presentation, I was struck by the vastness and depth of this topic. One particular number caught my attention and made me pause.

According to the Center for Biological Diversity, there are 50,000 – 80,000 plants used for medicinal purposes worldwide. This number is staggering, considering my limited knowledge of only a few hundred plants.
The ancient wisdom of herbal medicine is practiced globally and supported by extensive international research in regions such as the Near East, Russia, East Africa, North East India, and even Transylvania. The list goes on.

New Review Reapproves Plants’ Anti-Cancer Qualities

In recent years, there has been a resurgence of interest in learning more about the medicinal properties of plants. This renewed focus on ancient wisdom may be driven by the need to find remedies for diseases that modern medicine struggles to treat effectively.

A 2024 review published in the journal Pharmaceuticals aligns with this trend. The review highlights 15 medicinal plants with potential anti-tumorigenic properties, indicating that these plants contain active compounds that combat abnormal cell growth.
What caught my attention were the plants featured in the review. Some of them are familiar, with extensive literature written about them, such as dandelion, nettles, and the well-known turmeric.

Other plants like the Madagascar periwinkle (Catharanthus roseus), tropical soursop, and even the houseplant Kalanchoe blossfeldiana may be less familiar to many.

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Nevertheless, all these plants share a common trait—they are effective against the majority of common types of cancer, as stated in the headline of the review.

Efficient Treatment for Immediate Development

The International Agency for Research on Cancer paints a bleak picture of the worldwide cancer situation. Their 2022 report indicates that globally, lung cancer (18.7 percent), colorectal cancer (9.3 percent), and liver cancer (7.8 percent) were the leading causes of cancer-related deaths, accounting for a total of 3,480,213 individuals.

In response, the researchers of the recent review call for the immediate development of “more targeted and efficient treatment plans.” According to them, “Plants and products derived from them show promising potential as sources of less toxic anticancer drugs.”

Blending Traditional Wisdom and Novel Nanotechnologies

Herbs are utilized to bolster the immune system, eliminate carcinogens, and enhance antioxidant levels in our bodies to achieve this goal. Scientists are exploring the use of new nanomedicines and bioengineering techniques for immune cell therapies as innovative approaches to combat the disease.

As a community herbalist, I approach this with a focus on longevity. What traditional wisdom surrounding these herbs has been passed down through the centuries? How can we combine the realms of modern research and ancient knowledge to benefit the patient?

Anti-Cancer Plants: Research and Application

The recent review highlights several herbs that may thrive abundantly in our gardens, often seen as bothersome weeds that need to be removed. Dandelions are a classic example of this.

One of the most robust perennial herbaceous plants, Taraxacum officinale, commonly known as dandelion, serves not only as a medicinal herb but also as an edible vegetable. The tender young leaves add a slightly bitter flavor to salads, aiding in digestion.

The Taraxacum genus comprises over 300 species that have been utilized in traditional and folk medicines for centuries. As early as the 16th century, German botanist Leonhart Fuchs lauded the plant’s health benefits in his herbal compendium, “De Historia Stirpium.”
Dandelion has also been recognized for its medicinal properties in Arabian medicine since the 10th century. Indian and Chinese medicine have historically used dandelion to treat liver and digestive diseases, as mentioned in an article published in the National Library of Medicine.

The dandelion boasts a wide array of vitamins such as A, C, B, and D, along with minerals like potassium, calcium, and traces of iron, magnesium, manganese, and zinc.

A 2023 review thoroughly examined the dandelion and noted its bioactive compounds. The plant’s therapeutic potential, including anti-bacterial, antioxidant, anticancer, and anti-rheumatic activities, is sourced from components like sesquiterpenoids and phenolic compounds.
Research in Korea demonstrated the relationship between the content of phenols and flavonoids in the plant and its antioxidant and anticancer properties. While this varies among different taraxacum species, it is abundant in the common dandelion.
A 2023 study investigated a combination of dandelion extracts. Published in the journal Scientific Reports, the results highlighted the extract’s ability to inhibit the rapid proliferation and invasion of cancer cells, particularly in breast cancer, leading to cell death.
Photodynamic Therapy, a method for targeting cancerous tissue, was tested with dandelion in a 2023 article in Nanomedicine. This process aimed to achieve synergistic chemotherapy and photodynamic cancer therapy through the delivery of active compounds to cancer cells, disrupting their homeostasis and exhibiting anti-cancer and anti-tumor effects.

Stinging Nettle

A highly medicinal weed that competes with dandelion is Urtica dioica. Nettles are often seen as bothersome wildflowers in many temperate regions.

Contrary to popular belief, I recently transplanted some nettles into my garden and even sowed nettle seeds in an attempt to establish them. Nettles contribute plant nutrition and are a great addition to soups and salads, as their stinging hairs lose their potency when processed.

Rich in provitamin beta-carotene, vitamins A, B, and C, and minerals iron, magnesium, potassium, and calcium, this protein-rich perennial herb offers a plethora of health benefits.

A 2020 study explored the potential anticancer properties of nettles. The extract of Urtica dioica displayed significant effects on the proliferation rate of hepatocarcinoma and colon cancer cell lines at specific doses.
In a 2022 study published in the Asian Pacific Journal of Cancer Prevention, the anticancer properties of plant medicine were demonstrated against various types of cancer cell lines. Testing the cytotoxicity of urtica dioica was conducted in vitro and in vivo, showing favorable results indicating that nettles may combat breast cancer through their anti-tumoral properties.
Another study focused on the herb’s healing potential for human colon and gastric cancer. Nettles induced apoptosis and inhibited the proliferation of gastric and colorectal cancer cells while showing no toxic effects on normal cells.

Greater Burdock

Continuing with the exploration of wildflowers that grow in disturbed areas across the United States, we encounter burdock. This member of the Asteraceae family, like dandelion, can be found in various environments.

Burdock’s medicinal parts include roots, leaves, and seeds, with lappaol F, a natural lignan compound, being an anticancer agent that halts tumor cell growth by inducing cell cycle arrest, as evidenced in a 2021 study.

Despite the unclear mechanisms underlying burdock’s anticancer properties, the plant’s efficacy is evident, suggesting the potential development of an anticancer drug derived from this medicinal herb.

A review published in Inflammopharmacology underscores the traditional medicinal uses of burdock in Europe, North America, and Asia. It emphasizes the plant’s anti-inflammatory, detoxifying, and anti-tumor properties, particularly its potent inhibitory effects on pancreatic carcinoma growth.
Burdock has also shown efficacy against multi-drug resistant cancer cells. A study investigated six lignans found in burdock seeds, combining them as non-toxic chemotherapeutic agents that offer promising multidrug resistant reversal activities, validated in combination with the chemotherapy drug doxorubicin.

Remaining 12 Anti-Cancer Plants

The recent review discusses 15 plants with potential anti-tumorigenic properties, including soursop (Annona muricata), black calla (Arum palaestinum), hemp (Cannabis sativa), turmeric (Curcuma longa), licorice (Glycyrrhiza glabra), moringa (Moringa oleifera), hibiscus (Hibiscus rosa-sinensis), milk thistle (Silybum marianum), oleander (Nerium oleander), kalanchoe (Kalanchoe blossfeldiana), and ashwagandha (Withania somnifera L).

While some of these plants like turmeric, licorice, hemp, ashwagandha, hibiscus, and milk thistle are well-known beyond herbalist circles, others may be perceived more as decorative plants or houseplants, such as oleander, black calla, Madagascar periwinkle, and kalanchoe. Moringa, native to the Indian subcontinent and primarily used in Southern Asia, may seem the most unfamiliar.

However, all of these plants are renowned for their medicinal properties.

Ongoing Phytopharmaceutical Research

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