New Study Shows Coffee Compound Enhances Memory Function
Thinking of cutting coffee from your diet? Given new information about the effect of one of its compounds on cognitive function—you might reconsider.
Your morning cup of coffee may be giving you more than just an energy boost. According to new research, trigonelline, a compound found in coffee and certain vegetables, can improve cognitive decline, spatial learning, and memory.
Researchers found that trigonelline significantly improved spatial learning and memory in aged mice. It was also found to support multiple pathways within the nervous system, decrease inflammation within the brain, and increase neurotransmitter levels.
Study Findings Explained
The study was conducted over a 16-week period using mice, to which the researchers administered trigonelline every day for 30 days followed by a water maze test. The researchers found that the mice demonstrated a significant improvement in their spatial learning and memory performance compared with the mice that did not receive trigonelline.
The researchers also wished to investigate the effects of trigonelline on brain matter, as well as specific neurotransmitters within the brain. The study revealed suppressed neuroinflammation within the brain tissue and higher levels of the neurotransmitters dopamine, noradrenaline, and serotonin.
What Is Trigonelline?
Trigonelline is a naturally occurring compound found in various plants. A byproduct of Vitamin B3 (also known as niacin), trigonelline is often found in high levels in coffee beans, fenugreek, and Japanese radish, and in lower levels in foods including oats, barley, potatoes, onions, tomatoes, and peas. In various studies, trigonelline has been reported to provide some protection against brain aging and cognitive decline, including neurological disorders such as Alzheimer’s and dementia.
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How Does Trigonelline Help to Boost Memory and Cognition?
Trigonelline provides neuroprotective factors due to its antioxidant, anti-inflammatory, and anti-cell death properties. Antioxidants play a crucial role in counteracting free radicals which can damage cells within the body and contribute to poor aging, as well as various diseases. Anti-inflammatories help reduce systemic inflammation and stress within the body, which can also cause long-term brain cell damage or even brain cell death.
“While consuming these foods and beverages is generally safe, too much coffee can cause anxiety, digestive distress, and elevate blood pressure. Strategies aimed at optimizing cognitive function as we age should include foundations of regular exercise, brain healthy diet, adequate sleep, stress management, toxin avoidance, and social interaction,” explains Ms. Sandison. As always, it is recommended to consult with your health care provider before making any significant dietary changes.
While more research is needed to fully understand the extent of trigonelline’s impact on neurocognitive health, preliminary studies are encouraging. Nevertheless, based on the current research, including trigonelline as part of a natural approach to brain health as we age may be beneficial.
