New Study Reveals California Tops the Nation in Overdose Death Rates
The report highlighted trends related to drug overdoses in the state and the financial repercussions of the fentanyl epidemic in California.
The study revealed that fentanyl was responsible for 70 percent—or 74,702—of all drug overdose deaths across the nation in 2023.
Furthermore, California experienced the highest state toll with 12,835 overdose fatalities in just one year, according to the findings.
The report indicated that the state’s “porous border” and close proximity to Mexico render it particularly vulnerable to the fentanyl crisis, noting that 90 percent of the fentanyl consumed in the U.S. originates from Mexico.
The prevalence of drug use among at-risk groups, such as immigrants and agricultural workers, has notably affected California more than other states.
Other results indicated that relapse rates among fentanyl users reached up to 95 percent, which is significantly above the relapse rates for other substances, including heroin (78 percent) and alcohol (68 percent).
Annual healthcare expenses related to opioid overdoses amount to $11 billion nationwide, with critical care costs averaging $20,500 per patient, according to the report.
Young people are particularly at risk, as overdose deaths among adolescents surged by nearly 50 percent from 2019 to 2020, as indicated in the report.
“The potency of fentanyl is alarmingly high, which leads to swift dependence even among those prescribed the drug,” the report noted. “Adolescents are especially vulnerable to this drug due to unsafe experimentation with unregulated pills.”
The study underscored the importance of effective treatments, including medication-assisted therapy, behavioral counseling, and inpatient rehabilitation, to tackle fentanyl addiction.

Authorities discovered packages of fentanyl concealed within carne asada beef during a routine traffic stop along Interstate 5 in Fresno County, California, on October 3, 2024. California Highway Patrol
The report recommended medications such as Buprenorphine, methadone, and naltrexone to stabilize brain chemistry, alleviate cravings, and mitigate withdrawal symptoms.
Additionally, the report emphasized the efficacy of drug courts and alternative sentencing in decreasing the rates of re-incarceration and aiding offenders in reintegrating into societal structures.
The opioid crisis has already cost the U.S. economy approximately $1.02 trillion in 2017, the group reported.
In California, the overall cost was around $36 billion, according to the findings.
This figure encompasses lost productivity, healthcare expenses, and the broader social consequences of addiction on families and communities.
The foundation’s findings additionally revealed that opioid overdose death rates were highest among American Indian populations in 2023, followed by Black, White, and Hispanic populations. Among these, Asians and Pacific Islanders exhibited the lowest death rate.