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Study Shows Sugar-Free Gum Can Help Reduce Rates of Preterm Birth


A study conducted in Africa found that pregnant women who chewed xylitol-sweetened gum experienced a 30 percent reduction in very-low-birth-weight babies.

Chewing xylitol gum could potentially help prevent preterm birth.

Research involving over 10,000 pregnant women in Malawi showed that those who chewed sugar-free, xylitol-sweetened gum had a 24 percent lower incidence of preterm birth compared to those who did not.

Xylitol is a sugar-free sweetener derived from xylose, extracted from birch trees and corn cobs. Preterm birth occurs when a baby is born before 37 weeks of pregnancy.

“It surprised us all that such a simple intervention could have such a dramatic effect,” stated Dr. Greg Valentine, associate professor of pediatrics at the University of Washington School of Medicine and lead author of the study, in a press statement.

Xylitol Linked to About 30 Percent Fewer Preterm Births

The findings, published in Med, a journal by Cell Press, suggest a simple solution for a significant health challenge in the region.

The study, conducted from May 2015 to October 2018, followed more than 10,000 participants from eight health centers across Malawi. 4,549 pregnant women were assigned to receive xylitol-containing gum, showing a 30 percent decrease in very-low-birth-weight babies and 24 percent fewer preterm births compared to the control group.

Low-birth-weight babies are born weighing under 5 pounds, 8 ounces, with very-low-birth-weight babies weighing under 3 pounds, 4 ounces.

Gum Disease Linked to Preterm Birth

Previous studies have shown that periodontal disease can increase the risk of preterm birth and low-birth-weight deliveries by two to three times.

While the exact mechanism remains unclear, it is speculated to involve the inflammatory response related to periodontal disease or bacterial spread.
“Periodontal disease’s association with preterm birth is particularly significant in Malawi, where about 70% of pregnant individuals have gum disease,” explained Valentine.

How Xylitol Works Beyond Cavity Prevention

Researchers noted that xylitol has probiotic properties and can reduce bacteria growth related to periodontal disease and gum tissue inflammation.

The participants chewed xylitol gum from early pregnancy until delivery, leading to improved oral health more effectively than traditional methods, especially in low-resource settings.

While the study’s findings are specific to Malawi and require validation in other regions, Dr. Valentine emphasized the importance of confirming results in the United States and globally.

Future Research Plans

A follow-up study in Malawi called the Prevention of Developmental Delay and Xylitol study will investigate the neurodevelopmental outcomes of 1,000 children born during the initial trial, with results expected in 2027.

The researchers also plan to test the xylitol-gum intervention in lower-resourced communities in the Seattle area to assess its effectiveness.

Dr. Valentine warns against high xylitol intake, as it can lead to gastrointestinal issues such as diarrhea, upset stomach, and bloating.



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