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Study Finds That Puberty Blocker Use in Boys Can Lead to Permanent Testicular Atrophy and Irreversible Damage to Fertility


A recent study indicates that the use of puberty blockers in boys may lead to permanent damage to their reproductive organs and irreversible impairment of fertility. This challenges the notion that puberty blockers are a harmless way for individuals to explore their gender identity.

The study, conducted by the Mayo Clinic and published in late March (not yet peer-reviewed), examined a large collection of pediatric testicular samples from teenage boys with gender dysphoria who were treated with chronic puberty blockers. The researchers observed gland atrophy and abnormal cellular changes, indicating potential long-lasting harm to reproductive capabilities.

Specifically, the researchers noted varying degrees of sex gland atrophy in children treated with puberty blockers. Additionally, by analyzing testicular cells at a microscopic level and using advanced computational techniques, they raised concerns about irreversible damage to spermatogonial stem cells, which are crucial for sperm production and male fertility.

Despite preliminary findings of the study, the Mayo Clinic website states that puberty blockers do not result in permanent physical changes but merely pause puberty, providing an opportunity for gender exploration.

The researchers emphasized the need for further investigation into the long-term effects of puberty blockers on reproductive health in adolescent boys, as well as the impact on spermatogonial stem cells. They stressed the urgency of confirming their initial findings regarding testicular atrophy and fertility impairment caused by puberty blockers.

Public Concerns

The study has drawn attention from critics of puberty blocker use in adolescents, including prominent figures like J.K. Rowling. She criticized a UK-based gender clinic for promoting easy access to puberty blockers despite the potential risks identified in the Mayo Clinic report.

Other critics, such as Genevieve Gluck, have highlighted previous evidence suggesting harm from puberty blockers in women. They argue that the claims of reversibility and mental health benefits associated with puberty blockers are not supported by scientific evidence.

Moreover, scientific studies have shown that gender transition procedures like puberty blockers and cross-sex hormones do not provide mental health benefits to youth with gender dysphoria, according to a recent policy statement by the American College of Pediatricians.

Based on the available data, concerns have been raised about the potential impact of hormone therapy on gender identity development in adolescents. Reports from different countries indicate uncertainty about the benefits and risks associated with puberty blockers in individuals with gender dysphoria.



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